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lüll Recombination and chromosome segregation Sherratt DJ; Soballe B; Barre FX; Filipe S; Lau I; Massey T; Yates JPhilos Trans R Soc Lond B Biol Sci 2004[Jan]; 359 (1441): 61-9The duplication of DNA and faithful segregation of newly replicated chromosomes at cell division is frequently dependent on recombinational processes. The rebuilding of broken or stalled replication forks is universally dependent on homologous recombination proteins. In bacteria with circular chromosomes, crossing over by homologous recombination can generate dimeric chromosomes, which cannot be segregated to daughter cells unless they are converted to monomers before cell division by the conserved Xer site-specific recombination system. Dimer resolution also requires FtsK, a division septum-located protein, which coordinates chromosome segregation with cell division, and uses the energy of ATP hydrolysis to activate the dimer resolution reaction. FtsK can also translocate DNA, facilitate synapsis of sister chromosomes and minimize entanglement and catenation of newly replicated sister chromosomes. The visualization of the replication/recombination-associated proteins, RecQ and RarA, and specific genes within living Escherichia coli cells, reveals further aspects of the processes that link replication with recombination, chromosome segregation and cell division, and provides new insight into how these may be coordinated.|*DNA Replication[MESH]|Adenosine Triphosphatases/metabolism[MESH]|Chromosome Segregation/*physiology[MESH]|DNA Helicases/metabolism[MESH]|Escherichia coli[MESH]|Escherichia coli Proteins[MESH]|Membrane Proteins/metabolism[MESH]|RecQ Helicases[MESH]|Recombination, Genetic/*physiology[MESH] |