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D-dimers in the emergency department evaluation of aortic dissection Perez A; Abbet P; Drescher MJAcad Emerg Med 2004[Apr]; 11 (4): 397-400Aortic dissection (AD) is the most common acute aortic condition requiring urgent surgery. AD, if not diagnosed in the emergency department (ED), is frequently fatal. AD is a difficult antemortem diagnosis. OBJECTIVES: To determine if acute AD is associated with an elevation of fibrin degradation products, D-dimers. METHODS: This was a retrospective chart review of patients diagnosed as having AD in the ED in whom a D-dimer determination was obtained in the ED, prior to any therapeutic intervention. The study was conducted in an urban Level I trauma center between October 1996 and September 2000. Exclusion criteria were referred patients with known diagnosis of AD. The D-dimer assay used was the semiquantitative latex agglutination assay, with a normal range up to 0.5 micro g/mL. RESULTS: One hundred fifty-six patients were diagnosed as having AD in the ED. Seven patients had a D-dimer assay during their workup. All seven had a positive test. CONCLUSIONS: All seven patients with an AD who had D-dimer assays performed in the ED had positive results by latex agglutination.|Aged[MESH]|Aortic Aneurysm/*blood/*diagnosis[MESH]|Aortic Dissection/*blood/*diagnosis[MESH]|Biomarkers/blood[MESH]|Emergency Medical Services/*methods[MESH]|Female[MESH]|Fibrin Fibrinogen Degradation Products/*analysis[MESH]|Humans[MESH]|Latex Fixation Tests[MESH]|Male[MESH]|Middle Aged[MESH]|Retrospective Studies[MESH] |
