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lüll 2 -O,4 -C-ethylene-bridged nucleic acids (ENA) as next-generation antisense and antigene agents Koizumi MBiol Pharm Bull 2004[Apr]; 27 (4): 453-6Novel 2'-O,4'-C-ethylene nucleosides have been synthesized as building blocks for antisense and antigene oligonucleotides. 2'-O,4'-C-Ethylene-bridged nucleic acids (ENA) comprising 2'-O,4'-C-ethylene nucleosides have considerable affinity to complementary RNA and double-stranded DNA. Incorporation of 2'-O,4'-C-ethylene nucleosides into oligonucleotides dramatically increase their resistance against exonucleases. In this review, the properties of ENA oligonucleotides and some of their applications as antisense and antigene oligonucleotides are described.|Bridged-Ring Compounds/chemical synthesis/chemistry[MESH]|Drug Stability[MESH]|Ethylenes/chemical synthesis/*chemistry[MESH]|Exonucleases/chemistry[MESH]|Molecular Conformation[MESH]|Nucleic Acids/chemical synthesis/*chemistry[MESH]|Oligonucleotides, Antisense/chemical synthesis/*chemistry[MESH] |