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Redox regulation of PTEN and protein tyrosine phosphatases in H(2)O(2) mediated cell signaling Cho SH; Lee CH; Ahn Y; Kim H; Kim H; Ahn CY; Yang KS; Lee SRFEBS Lett 2004[Feb]; 560 (1-3): 7-13Protein tyrosine phosphatase (PTP) is a family of enzymes important for regulating cellular phosphorylation state. The oxidation and consequent inactivation of several PTPs by H(2)O(2) are well demonstrated. It is also shown that recovery of enzymatic activity depends on the availability of cellular reductants. Among these redox-regulated PTPs, PTEN, Cdc25 and low molecular weight PTP are known to form a disulfide bond between two cysteines, one in the active site and the other nearby, during oxidation by H(2)O(2). The disulfide bond likely confers efficiency in the redox regulation of the PTPs and protects cysteine-sulfenic acid of PTPs from further oxidation. In this review, through a comparative analysis of the oxidation process of Yap1 and PTPs, we propose the mechanism of disulfide bond formation in the PTPs.|*Adaptor Proteins, Signal Transducing[MESH]|*Signal Transduction[MESH]|Animals[MESH]|Carrier Proteins/metabolism[MESH]|Cells/metabolism[MESH]|Disulfides/metabolism[MESH]|Humans[MESH]|Hydrogen Peroxide/*toxicity[MESH]|Models, Biological[MESH]|Models, Molecular[MESH]|Oxidants/*toxicity[MESH]|Oxidation-Reduction[MESH]|Phosphoproteins/metabolism[MESH]|Phosphorylation[MESH]|Protein Kinases/*metabolism[MESH]|Protein Tyrosine Phosphatases/*metabolism[MESH]|Transcription Factors[MESH]|YAP-Signaling Proteins[MESH] |
