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lüll The influence of follicular migration on T-cell differentiation Smith KM; Brewer JM; Mowat AM; Ron Y; Garside PImmunology 2004[Mar]; 111 (3): 248-51The sequence of events that leads to the development of a T-dependent B-cell response has been studied for many years and much attention has focused on the importance of these interactions for the B cell and the antibody response. While a role for B cells in T-cell memory has been demonstrated, the cellular and molecular mechanisms underlying this are unclear and the importance for T cells to migrate into follicles and interact with B cells has received relatively little attention. These interactions between T and B lymphocytes are facilitated by a co-ordinated series of migration events within lymph nodes and here we propose that this migration and these events are essential for the terminal differentiation of all CD4+ T cells and without it tolerance may result.|Animals[MESH]|Antibody Formation/immunology[MESH]|B-Lymphocytes/*immunology[MESH]|CD4-Positive T-Lymphocytes/immunology[MESH]|Cell Differentiation/immunology[MESH]|Cell Movement/immunology[MESH]|Humans[MESH]|Immune Tolerance/immunology[MESH]|Immunity, Cellular/immunology[MESH]|Immunologic Memory/immunology[MESH]|Lymph Nodes/*immunology[MESH]|Mice[MESH]|Models, Immunological[MESH]|T-Lymphocytes/*immunology[MESH] |