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lüll Aurora-A overexpression leads to override of the microtubule-kinetochore attachment checkpoint Dutertre S; Prigent CMol Interv 2003[May]; 3 (3): 127-30The amplification of AURORA-A is frequently observed in specific epithelial cell malignancies. The overexpression of aurora-A, a Ser-Thr kinase known to localize to centrosomes during mitosis, appears to imbue cancerous cells with resistance to spindle-checkpoint-targeting drugs such as paclitaxel (Taxol). Indeed, a recent publication by Anand et al. indicates that overexpression of AURORA-A may interfere with spindle-microtubule attachment and disrupt the regulation of the spindle checkpoint by allowing cells with abnormal chromosomal separation to enter anaphase. Thus, the design of new drugs that specifically target aurora-A rather than other checkpoint proteins might alleviate the resistance to Taxol-like clinical therapeutics observed in some tumors.|Anaphase[MESH]|Animals[MESH]|Apoptosis[MESH]|Aurora Kinase A[MESH]|Aurora Kinases[MESH]|Caenorhabditis elegans[MESH]|Calcium-Binding Proteins/metabolism[MESH]|Cell Cycle Proteins[MESH]|Cell Line[MESH]|Centrosome/ultrastructure[MESH]|Drosophila melanogaster[MESH]|HeLa Cells[MESH]|Humans[MESH]|Kinetochores/*ultrastructure[MESH]|Mad2 Proteins[MESH]|Metaphase[MESH]|Mice[MESH]|Microtubules/*ultrastructure[MESH]|Models, Biological[MESH]|Protein Kinases/*biosynthesis/*physiology[MESH]|Protein Serine-Threonine Kinases[MESH]|Repressor Proteins[MESH]|Saccharomyces cerevisiae[MESH]|Xenopus Proteins[MESH] |