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Lower risk for tardive dyskinesia associated with second-generation antipsychotics: a systematic review of 1-year studies Correll CU; Leucht S; Kane JMAm J Psychiatry 2004[Mar]; 161 (3): 414-25OBJECTIVE: Based on lower rates of acute extrapyramidal side effects associated with second-generation antipsychotics, compared to first-generation antipsychotics, and based on preliminary data, second-generation antipsychotics are expected to cause less tardive dyskinesia than first-generation antipsychotics. This hypothesis was examined in a systematic review of studies involving open or controlled treatment with any second-generation antipsychotic. METHOD: Studies of treatment with second-generation antipsychotics lasting > or =1 year and reporting on new cases of tardive dyskinesia or dyskinesia were systematically reviewed. RESULTS: In 11 studies, 2,769 patients received treatment with risperidone (five studies, N=1,235), olanzapine (two studies, N=610), quetiapine (two studies, N=386), amisulpride (one study, N=331), or ziprasidone (one study, N=207) for a weighted mean and median duration of 263 and 306 days, respectively. Study designs were double blind and randomized (N=3); open-label extensions of double-blind, randomized trials (N=4); and open label (N=4). Of the four trials that had a comparator (all involving adults with schizophrenia spectrum disorders), three used haloperidol (N=408) and one used placebo (N=71). Studied populations included children (N=77), adults (N=1,419), adults and elderly persons (N=794), and exclusively patients age 54 years or older (N=479). The weighted mean annual incidence of tardive dyskinesia for second-generation antipsychotics was 0% in the children, 0.8% (range=0.0%-1.5%) in the adults, 6.8% in the mixed adult and elderly population, and 5.3% (range=0.0%-13.4%) in the patients age 54 years and older, compared to 5.4% (range=4.1%-7.4%) in adults treated with haloperidol. CONCLUSIONS: Results from 11 long-term studies support the idea that second-generation antipsychotics have a reduced risk for tardive dyskinesia, compared to first-generation antipsychotics, although the doses of haloperidol used in the comparator studies were relatively high. More carefully designed studies, ideally lasting beyond 1 year and comparing the effects of different second-generation antipsychotics in patients who have never taken first-generation antipsychotics, are needed to estimate the true risk. It would not appear premature for clinicians to consider these findings in making long-term treatment decisions.|Adolescent[MESH]|Adult[MESH]|Aged[MESH]|Amisulpride[MESH]|Antipsychotic Agents/*adverse effects/therapeutic use[MESH]|Benzodiazepines/adverse effects/therapeutic use[MESH]|Child[MESH]|Dibenzothiazepines/adverse effects/therapeutic use[MESH]|Double-Blind Method[MESH]|Dyskinesia, Drug-Induced/diagnosis/*etiology[MESH]|Haloperidol/adverse effects/therapeutic use[MESH]|Humans[MESH]|Middle Aged[MESH]|Neurologic Examination/drug effects[MESH]|Olanzapine[MESH]|Piperazines/adverse effects/therapeutic use[MESH]|Quetiapine Fumarate[MESH]|Randomized Controlled Trials as Topic[MESH]|Risk[MESH]|Sulpiride/adverse effects/*analogs & derivatives/therapeutic use[MESH]|Thiazoles/adverse effects/therapeutic use[MESH] |
