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lüll Regulation of notch signaling activity Schweisguth FCurr Biol 2004[Feb]; 14 (3): R129-38Cell-cell signalling mediated by the receptor Notch is used widely across the metazoans to determine cell fate and regulate pattern formation. Notch signals via a conserved regulated intramembrane proteolysis. Recent analyses of the cell biology of the Notch receptor have identified several fundamental mechanisms that contribute to regulate Notch signaling activity in space and time.|*Models, Biological[MESH]|Amyloid Precursor Protein Secretases[MESH]|Calcium-Binding Proteins[MESH]|Cell Communication/*physiology[MESH]|Cell Differentiation/physiology[MESH]|Drosophila Proteins/metabolism[MESH]|Endocytosis/physiology[MESH]|Endopeptidases/metabolism[MESH]|Fucosyltransferases/metabolism[MESH]|Intercellular Signaling Peptides and Proteins[MESH]|Jagged-1 Protein[MESH]|Juvenile Hormones/metabolism[MESH]|Ligands[MESH]|Membrane Proteins/*metabolism/physiology[MESH]|Protein Structure, Tertiary[MESH]|Receptors, Cell Surface/*metabolism/physiology[MESH]|Receptors, Notch[MESH]|Serrate-Jagged Proteins[MESH]|Signal Transduction/*physiology[MESH] |