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lüll Notch signaling: control of cell communication and cell fate Lai ECDevelopment 2004[Mar]; 131 (5): 965-73Notch is a transmembrane receptor that mediates local cell-cell communication and coordinates a signaling cascade present in all animal species studied to date. Notch signaling is used widely to determine cell fates and to regulate pattern formation; its dysfunction results in a tremendous variety of developmental defects and adult pathologies. This primer describes the mechanism of Notch signal transduction and how it is used to control the formation of biological patterns.|Animals[MESH]|Body Patterning[MESH]|Cell Communication/*physiology[MESH]|Drosophila Proteins/genetics/physiology[MESH]|Drosophila/genetics/growth & development[MESH]|Feedback[MESH]|Humans[MESH]|Membrane Proteins/genetics/*physiology[MESH]|Models, Biological[MESH]|Mutation[MESH]|Receptors, Notch[MESH]|Signal Transduction[MESH] |