Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes Keegan LP; Leroy A; Sproul D; O'Connell MAGenome Biol 2004[]; 5 (2): 209Adenosine deaminases acting on RNA (ADARs) were discovered as a result of their ability extensively to deaminate adenosines in any long double-stranded RNA, converting them to inosines. Subsequently, ADARs were found to deaminate adenosines site-specifically within the coding sequences of transcripts encoding ion-channel subunits, increasing the diversity of these proteins in the central nervous system. ADARI is now known to be involved in defending the genome against viruses, and it may affect RNA interference. ADARs are found in animals but are not known in other organisms. It appears that ADARs evolved from a member of another family, adenosine deaminases acting on tRNAs (ADATs), by steps including fusion of two or more double-stranded-RNA binding domains to a common type of zinc-containing adenosine-deaminase domain.|*RNA Editing[MESH]|Adenosine Deaminase/chemistry/*genetics/*physiology[MESH]|Amino Acid Sequence[MESH]|Animals[MESH]|Chordata, Nonvertebrate/genetics[MESH]|Evolution, Molecular[MESH]|Humans[MESH]|Molecular Sequence Data[MESH]|Protein Structure, Tertiary[MESH]|RNA-Binding Proteins[MESH]|Vertebrates/genetics[MESH] |