Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
Mammalian prion biology: one century of evolving concepts Aguzzi A; Polymenidou MCell 2004[Jan]; 116 (2): 313-27Prions have been responsible for an entire century of tragic episodes. Fifty years ago, kuru decimated the population of Papua New Guinea. Then, iatrogenic transmission of prions caused more than 250 cases of Creutzfeldt-Jakob disease. More recently, transmission of bovine spongiform encephalopathy to humans caused a widespread health scare. On the other hand, the biology of prions represents a fascinating and poorly understood phenomenon, which may account for more than just diseases and may represent a fundamental mechanism of crosstalk between proteins. The two decades since Stanley Prusiner's formulation of the protein-only hypothesis have witnessed spectacular advances, and yet some of the most basic questions in prion science have remained unanswered.|Animals[MESH]|Cattle[MESH]|Creutzfeldt-Jakob Syndrome/etiology[MESH]|Encephalopathy, Bovine Spongiform/etiology[MESH]|Fungal Proteins/physiology[MESH]|Humans[MESH]|Immunoassay/methods[MESH]|Models, Anatomic[MESH]|Models, Biological[MESH]|Prion Diseases/diagnosis[MESH]|Prions/metabolism/*physiology[MESH]|Protein Conformation[MESH] |
