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lüll Principles of tumor suppression Sherr CJCell 2004[Jan]; 116 (2): 235-46Molecular genetic studies of familial cancer syndromes identified and defined the recessive nature of tumor suppressor genes and resolved the paradox of why tumors arising in such families exhibited an autosomally dominant pattern of inheritance. Subsequent characterization of tumor suppressor proteins revealed their widespread involvement in sporadic cancers and pinpointed key mechanisms that protect animals against tumor development. We now recognize that tumor suppressor genes regulate diverse cellular activities, including cell cycle checkpoint responses, detection and repair of DNA damage, protein ubiquitination and degradation, mitogenic signaling, cell specification, differentiation and migration, and tumor angiogenesis. Their study has become a centerpiece of contemporary cancer research.|*Genes, Tumor Suppressor[MESH]|ADP-Ribosylation Factors/physiology[MESH]|Cell Cycle[MESH]|Cell Differentiation[MESH]|Cell Movement[MESH]|Cyclin-Dependent Kinase Inhibitor p16/metabolism[MESH]|DNA Damage[MESH]|DNA Repair[MESH]|Genetic Predisposition to Disease[MESH]|Ligands[MESH]|Models, Biological[MESH]|Neoplasms/etiology/genetics/*pathology[MESH]|Retinoblastoma Protein/metabolism[MESH]|Signal Transduction[MESH]|Tumor Suppressor Protein p53/physiology[MESH]|Ubiquitin/metabolism[MESH] |