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lüll Isozymes delta of phosphoinositide-specific phospholipase C and their role in signal transduction in the cell Ochocka AM; Pawelczyk TActa Biochim Pol 2003[]; 50 (4): 1097-110Phospholipase C (PLC, EC 3.1.4.11) is an enzyme crucial for the phosphoinositol pathway and whose activity is involved in eukaryotic signal transduction as it generates two second messengers: diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). There are four major types of phospholipase C named: beta, gamma, delta and the recently discovered epsilon, but this review will focus only on the recent advances for the delta isozymes of PLC. So far, four delta isozymes (named delta1-4) have been discovered and examined. They differ with regard to cellular distribution, activities, biochemical features and involvement in human ailments.|Active Transport, Cell Nucleus/physiology[MESH]|Animals[MESH]|Cattle[MESH]|Enzyme Activators[MESH]|Enzyme Inhibitors[MESH]|Humans[MESH]|Isoenzymes/genetics/metabolism[MESH]|Phosphoinositide Phospholipase C[MESH]|Phospholipase C delta[MESH]|Phosphoric Diester Hydrolases/genetics/*metabolism[MESH]|Protein Sorting Signals/genetics/physiology[MESH]|Rats[MESH]|Signal Transduction/*physiology[MESH] |