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lüll Discovery and development of anti-angiogenic peptides: A structural link Dings RP; Nesmelova I; Griffioen AW; Mayo KHAngiogenesis 2003[]; 6 (2): 83-91Cancer is a disease promoted by excess angiogenesis. Interference with this process poses an attractive approach to controlling aberrant tumor growth, a hypothesis first proposed in the early 1970s that led to world-wide focus on identifying and developing angiogenesis inhibitors, which currently number in the hundreds. This review surveys the discovery and development of anti-angiogenic protein fragments and peptides, with a slant towards understanding their structure-function relationships to aid in the design of better therapeutic agents.|Angiogenesis Inhibitors/chemistry/*metabolism/therapeutic use[MESH]|Animals[MESH]|Drug Design[MESH]|Endothelial Cells/metabolism[MESH]|Humans[MESH]|Neovascularization, Pathologic/drug therapy/*metabolism[MESH]|Peptide Fragments/chemistry/*metabolism/therapeutic use[MESH]|Peptides/chemistry/*metabolism/therapeutic use[MESH]|Structure-Activity Relationship[MESH] |