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Plasticity of T cell memory responses to viruses Selin LK; Welsh RMImmunity 2004[Jan]; 20 (1): 5-16Virus-specific memory T cell populations demonstrate plasticity in antigenic and functional phenotype, in recognition of antigen, and in their ability to accommodate new memory T cell populations. The adaptability of complex antigen-specific T cell repertoires allows the host to respond to a diverse array of pathogens and accommodate memory pools to many pathogens in a finite immune system. This is in part accounted for by crossreactive memory T cells, which can be employed in immune responses and mediate protective immunity or life-threatening immunopathology.|Animals[MESH]|Cross Reactions/immunology[MESH]|Humans[MESH]|Immunologic Memory/immunology/*physiology[MESH]|Influenza A virus/immunology[MESH]|Lymphocytic choriomeningitis virus/immunology[MESH]|Mice[MESH]|Muromegalovirus/immunology[MESH]|Phenotype[MESH]|Receptors, Antigen, T-Cell/immunology[MESH]|T-Lymphocytes/immunology/*physiology[MESH]|Virus Diseases/*immunology[MESH] |
