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  • Phagocytosis of opsonized apoptotic cells: roles for old-fashioned receptors for antibody and complement
  • Hart SP; Smith JR; Dransfield I
  • Clin Exp Immunol 2004[Feb]; 135 (2): 181-5
  • Efficient phagocytic clearance of apoptotic cells is crucial in many biological processes. A bewildering array of phagocyte receptors have been implicated in apoptotic cell clearance, but there is little convincing evidence that they act directly as apoptotic cell receptors. Alternatively, apoptotic cells may become opsonized, whereby naturally occurring soluble factors (opsonins) bind to the cell surface and initiate phagocytosis. Evidence is accumulating that antibodies and complement proteins opsonize apoptotic cells, leading to phagocytosis mediated by well-defined 'old-fashioned' receptors for immunoglobulin-Fc and complement. In this review we summarize the evidence that opsonization is necessary for high capacity clearance of apoptotic cells, which would render putative direct apoptotic cell receptors redundant.
  • |Acute-Phase Proteins/immunology[MESH]
  • |Antibodies/*immunology[MESH]
  • |Anticoagulants/immunology[MESH]
  • |Apoptosis/*immunology[MESH]
  • |Collectins/immunology[MESH]
  • |Complement System Proteins/*immunology[MESH]
  • |Humans[MESH]
  • |Immunoglobulin Fc Fragments/immunology[MESH]
  • |Immunoglobulin G/immunology[MESH]
  • |Opsonin Proteins/immunology[MESH]
  • |Phagocytosis/*immunology[MESH]
  • |Receptors, Complement/immunology[MESH]
  • |Receptors, Immunologic/*immunology[MESH]
  • |Serum/immunology[MESH]





  • *{{pmid14738443}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=14738443 Phagocytosis of opsonized apoptotic cells: roles for old-fashioned receptors for antibody and complement ]</b> Clin Exp Immunol 2004; 135(2) ; 181-5 Hart SP; Smith JR; Dransfield I

        *14738443*

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    Clin Exp Immunol

    181 2.135 2004