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Bayesian analysis and risk assessment in genetic counseling and testing Ogino S; Wilson RBJ Mol Diagn 2004[Feb]; 6 (1): 1-9Risk assessment is an essential component of genetic counseling and testing, and Bayesian analysis plays a central role in genetic risk assessment. Bayesian analysis allows calculation of the probability of a particular hypothesis, either disease or carrier status, based on family information and/or genetic test results. Genetic risk should be assessed as accurately as possible for family decision making. Additional information, from the pedigree and/or from genetic testing, can often dramatically improve the accuracy of genetic risk assessment. We illustrate herein the application of Bayes' theorem and describe important basic principles in genetic risk assessment.|*Bayes Theorem[MESH]|Cystic Fibrosis/diagnosis/genetics[MESH]|Female[MESH]|Genetic Carrier Screening[MESH]|Genetic Counseling/*statistics & numerical data[MESH]|Genetic Predisposition to Disease/genetics[MESH]|Genetic Testing/*statistics & numerical data[MESH]|Humans[MESH]|Male[MESH]|Models, Genetic[MESH]|Muscular Atrophy, Spinal/diagnosis/genetics[MESH]|Pedigree[MESH]|Risk Factors[MESH] |
