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lüll Review article: diagnosis and current therapy of Wilson s disease Ferenci PAliment Pharmacol Ther 2004[Jan]; 19 (2): 157-65Wilson's disease is an autosomal recessive inherited disorder of hepatic copper metabolism resulting in liver disease and/or neuropsychiatric disease. The diagnosis of neurological disease is straightforward if the following symptoms are present: Kayser-Fleischer rings, typical neurological symptoms and low serum ceruloplasmin levels. The diagnosis is more complex in patients presenting with liver diseases. None of the commonly used parameters alone allows a diagnosis with certainty. A combination of various laboratory parameters is necessary to firmly establish the diagnosis. In the future, limited mutation analysis may play an important diagnostic role. Recently, a group of international experts has proposed a score based on a variety of tests and clinical symptoms. The validity of this score needs to be assessed prospectively. Treatment requires life-long administration of copper chelators (d-penicillamine, trientine). A frequently used alternative is zinc. None of these treatments has been tested by prospective randomized controlled studies. Liver transplantation is reserved for severe or treatment-resistant cases with advanced liver disease, whilst experience with refractory neuropsychiatric disease is limited.|*Hepatolenticular Degeneration/diagnosis/genetics/therapy[MESH]|Antioxidants/therapeutic use[MESH]|Chelating Agents/therapeutic use[MESH]|Genetic Testing[MESH]|Humans[MESH]|Liver Transplantation[MESH]|Pedigree[MESH]|Zinc/therapeutic use[MESH] |