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Acromegaly with fibrous dysplasia: McCune-Albright Syndrome -- clinical studies in 3 cases and brief review of literature-- Bhansali A; Sharma BS; Sreenivasulu P; Singh P; Vashisth RK; Dash RJEndocr J 2003[Dec]; 50 (6): 793-9The McCune-Albright syndrome (MAS) is characterized by a triad of poly/monostotic fibrous dysplasia, cafe-au-lait macules and hyperfunctioning endocrinopathies including growth hormone (GH) excess. Polyostotic bone lesions and cafe-au-lait macules are common while monostotic bone lesions are rare. Similarly, acromegaly as a manifestation of endocrine hyperfunction with MAS is uncommon and in most of the instances somatotropinoma has not been documented. We report 3 patients, two of them had monostotic lesion, none had cafe-au-lait macules and all had GH secreting pituitary macroadenoma. All of them underwent transfrontal pituitary adenomectomy and had histopathological confirmation of GH secreting pituitary adenoma. A brief review of literature is also presented.|Acromegaly/*complications[MESH]|Adenoma/*complications/diagnosis/metabolism/surgery[MESH]|Adult[MESH]|Fibrous Dysplasia, Monostotic/*complications[MESH]|Fibrous Dysplasia, Polyostotic/*complications[MESH]|Human Growth Hormone/*metabolism[MESH]|Humans[MESH]|Male[MESH]|Pituitary Neoplasms/*complications/diagnosis/metabolism/surgery[MESH]|Tomography, X-Ray Computed[MESH] |
