Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
 free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
 free
 free
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
It takes two to tango: mast cell and Schwann cell interactions in neurofibromas Viskochil DHJ Clin Invest 2003[Dec]; 112 (12): 1791-3Neurofibromas are benign tumors comprised primarily of Schwann cells and fibroblasts. Mast cell infiltration is a well-known phenomenon; however, their role in tumor pathogenesis has been enigmatic. In an elegant set of experiments using cells derived from a murine model of neurofibromatosis 1 (NF1), Yang et al. dissect the molecular pathways involved in mast cell migration to neurofibromin-deficient Schwann cells. These results set the stage for rational development of therapeutics that could influence the multicellular microenvironment of neurofibromas to inhibit the development and/or progression of these tumors in human NF1.|Alleles[MESH]|Animals[MESH]|Disease Progression[MESH]|Fibroblasts/metabolism[MESH]|Humans[MESH]|Mast Cells/*metabolism[MESH]|Mice[MESH]|Mice, Transgenic[MESH]|Models, Biological[MESH]|Mutation[MESH]|Neoplasms/metabolism[MESH]|Neurofibroma/*metabolism[MESH]|Neurofibromin 1/metabolism[MESH]|Schwann Cells/*metabolism[MESH]|Signal Transduction[MESH]|Stem Cell Factor/metabolism[MESH] |
