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lüll Fibulins: physiological and disease perspectives Argraves WS; Greene LM; Cooley MA; Gallagher WMEMBO Rep 2003[Dec]; 4 (12): 1127-31The fibulins are a family of proteins that are associated with basement membranes and elastic extracellular matrix fibres. This review summarizes findings from studies of animal models of fibulin deficiency, human fibulin gene mutations, human tumours and injury models that have advanced our understanding of the normal and pathological roles of members of this formerly obscure family.|Amino Acid Sequence[MESH]|Animals[MESH]|Basement Membrane/metabolism[MESH]|Calcium-Binding Proteins/chemistry/genetics/*physiology[MESH]|Cardiovascular System/metabolism[MESH]|Elastic Tissue/metabolism[MESH]|Extracellular Matrix Proteins/genetics/metabolism/physiology[MESH]|Gene Expression Regulation[MESH]|Humans[MESH]|Mice[MESH]|Mice, Knockout[MESH]|Models, Animal[MESH]|Molecular Sequence Data[MESH]|Neoplasms/genetics/metabolism[MESH]|Recombinant Proteins[MESH]|Wounds and Injuries/genetics/metabolism[MESH] |