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Genetic variability of hepatitis A virus Costa-Mattioli M; Napoli AD; Ferre V; Billaudel S; Perez-Bercoff R; Cristina JJ Gen Virol 2003[Dec]; 84 (Pt 12): 3191-3201Knowledge of the molecular biology of hepatitis A virus (HAV) has increased exponentially since its identification. HAV exploits all known mechanisms of genetic variation to ensure survival, including mutation and genetic recombination. HAV has been characterized by the emergence of different genotypes, three human antigenic variants and only one major serotype. This paper reviews the genetic variability and molecular epidemiology of HAV. Its evolutionary mechanisms are described with particular emphasis on genetic recombination and HAV mutation rate. Genotypic classification methods are also discussed.|*Genetic Variation[MESH]|Amino Acid Sequence[MESH]|Antigenic Variation[MESH]|Biological Evolution[MESH]|Canada/epidemiology[MESH]|Europe/epidemiology[MESH]|Genotype[MESH]|Hepatitis A Antigens/genetics[MESH]|Hepatitis A Virus, Human/classification/*genetics[MESH]|Hepatitis A/epidemiology[MESH]|Humans[MESH]|Incidence[MESH]|Molecular Epidemiology[MESH]|Molecular Sequence Data[MESH]|Mutation[MESH]|RNA, Viral/genetics[MESH]|Recombination, Genetic[MESH]|Sequence Alignment[MESH]|South America/epidemiology[MESH] |
