Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
Warning: file_get_contents(http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=14616166&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 445
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Fistula response to methotrexate in Crohn s disease: a case series Mahadevan U; Marion JF; Present DHAliment Pharmacol Ther 2003[Nov]; 18 (10): 1003-8BACKGROUND: Controlled trials have demonstrated the efficacy of methotrexate in the induction and maintenance of remission in luminal Crohn's disease; however, its effect on fistulizing disease is unknown. AIM: To describe the response to methotrexate therapy in a series of patients with fistulizing Crohn's disease. METHODS: A retrospective chart review was conducted of all patients with Crohn's disease receiving methotrexate in one practice. The response of patients with fistulizing and luminal disease was assessed using clinical and laboratory criteria. Fistula response was categorized as either complete or partial closure. RESULTS: Thirty-seven courses of methotrexate therapy were given to 33 patients with luminal and/or fistulizing Crohn's disease. In 16 patients with fistulas, four (25%) had complete closure, five (31%) had partial closure and all had failed or were intolerant to 6-mercaptopurine therapy. Overall, response to methotrexate was seen in 23 of 37 (62%) treatment courses in patients with luminal and/or fistulizing Crohn's disease. Two of the 33 patients (6%) had a significant adverse event. CONCLUSIONS: In this case series, 56% of patients with Crohn's fistulas on methotrexate showed a complete or partial response to therapy. Further studies are needed to confirm the role of methotrexate alone, and in combination with other therapies, for the treatment of fistulizing Crohn's disease.|Abdominal Wall[MESH]|Administration, Oral[MESH]|Adolescent[MESH]|Adult[MESH]|Aged[MESH]|Crohn Disease/complications/*drug therapy[MESH]|Cutaneous Fistula/complications/drug therapy[MESH]|Cyclosporine/therapeutic use[MESH]|Female[MESH]|Gastrointestinal Agents/*therapeutic use[MESH]|Humans[MESH]|Injections, Intramuscular[MESH]|Intestinal Fistula/complications/*drug therapy[MESH]|Male[MESH]|Mercaptopurine/therapeutic use[MESH]|Middle Aged[MESH]|Rectal Diseases/complications/drug therapy[MESH]|Retrospective Studies[MESH]|Treatment Outcome[MESH]|Urinary Bladder Diseases/complications/drug therapy[MESH]|Urinary Fistula/complications/drug therapy[MESH]|Vaginal Fistula/complications/drug therapy[MESH] |