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Intrauterine undernutrition--renal and vascular origin of hypertension do Carmo Pinho Franco M; Nigro D; Fortes ZB; Tostes RC; Carvalho MH; Lucas SR; Gomes GN; Coimbra TM; Gil FZCardiovasc Res 2003[Nov]; 60 (2): 228-34A large number of clinical and experimental studies supports the hypothesis that intrauterine undernutrition is an important determinant of hypertension, coronary heart disease and non-insulin-dependent diabetes in the adult offspring. In this review, the renal and vascular repercussions of maternal undernutrition are emphasized, and the physiopatologic mechanisms discussed. The origin of hypertension is detailed based upon the findings of kidney functional parameters and endothelium function studies. A working model linking hypertension to intrauterine undernutrition is proposed.|*Maternal Nutritional Physiological Phenomena[MESH]|Animals[MESH]|Arginine/metabolism[MESH]|Biological Availability[MESH]|Embryonic and Fetal Development[MESH]|Endothelium, Vascular/physiopathology[MESH]|Estrogens/metabolism[MESH]|Female[MESH]|Fetal Growth Retardation/*complications[MESH]|Gender Identity[MESH]|Gestational Age[MESH]|Glucocorticoids/metabolism[MESH]|Humans[MESH]|Hypertension/*etiology/metabolism/physiopathology[MESH]|Kidney/embryology/physiopathology[MESH]|Male[MESH]|Nitric Oxide/metabolism[MESH]|Pregnancy[MESH]|Rats[MESH]|Vasomotor System/physiology[MESH] |
