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lüll Angiogenesis in the corpus luteum Fraser HM; Wulff CReprod Biol Endocrinol 2003[Nov]; 1 (ä): 88The corpus luteum (CL) is a site of intense angiogenesis. Within a short period, this is followed either by controlled regression of the microvascular tree in the non-fertile cycle, or maintenance and stabilisation of the new vasculature a conceptual cycle. The molecular regulation of these diverse aspects is examined. The CL provides a unique model system in which to study the cellular and molecular regulation of angiogenesis. Vascular endothelial growth factor (VEGF) has been found to have a major role in the CL. By targeting its action at specific stages of the luteal phase in vivo by antagonists, profound inhibitory effects on luteal angiogenesis and function are observed.|Animals[MESH]|Corpus Luteum/*blood supply/cytology[MESH]|Female[MESH]|Humans[MESH]|Luteal Phase/blood/physiology[MESH]|Neovascularization, Physiologic/*physiology[MESH]|Pregnancy[MESH] |