Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
free
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
free free
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll The cholinergic anti-inflammatory pathway: a missing link in neuroimmunomodulation Pavlov VA; Wang H; Czura CJ; Friedman SG; Tracey KJMol Med 2003[May]; 9 (5-8): 125-34This review outlines the mechanisms underlying the interaction between the nervous and immune systems of the host in response to an immune challenge. The main focus is the cholinergic anti-inflammatory pathway, which we recently described as a novel function of the efferent vagus nerve. This pathway plays a critical role in controlling the inflammatory response through interaction with peripheral a7 subunit-containing nicotinic acetylcholine receptors expressed on macrophages. We describe the modulation of systemic and local inflammation by the cholinergic anti-inflammatory pathway and its function as an interface between the brain and the immune system. The clinical implications of this novel mechanism also are discussed.|*Immune System/drug effects[MESH]|Animals[MESH]|Antibody Formation/immunology[MESH]|Brain/drug effects/*immunology/metabolism[MESH]|Cholinergic Agents/*pharmacology[MESH]|Humans[MESH]|Inflammation/drug therapy/immunology/*metabolism[MESH]|Neuroimmunomodulation/drug effects/immunology/*physiology[MESH]|Vagus Nerve/metabolism[MESH] |