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Sphingosine-1-phosphate signaling in endothelial activation Ozaki H; Hla T; Lee MJJ Atheroscler Thromb 2003[]; 10 (3): 125-31The signaling and functions of the Endothelial Differentiation Gene (EDG) family of G protein-coupled receptors have been extensively elucidated. All the members of EDG family were shown to be receptors for lysosphingolipids or lysophospholipids. EDG-1, the prototype of EDG family receptors, is a high affinity receptor for serum-borne bioactive lipid, Sphingosine-1-phosphate (S1P). S1P, secreted by thrombotic platelets, has been shown to regulate a variety of cellular responses, including survival, cytoskeletal remodeling, chemotaxis etc, via the activation of cell surface EDG receptors. Recently, a novel function of S1P in modulating angiogenic response has been demonstrated. This review will focus on S1P/ EDG-1 signaling in endothelial activation, in particular in the S1P-mediated adherens junctions assembly and chemotaxis in endothelial cells.|*Lysophospholipids[MESH]|Endothelium, Vascular/*physiology[MESH]|Humans[MESH]|Immediate-Early Proteins/physiology[MESH]|Neovascularization, Physiologic/physiology[MESH]|Platelet Activation/*physiology[MESH]|Receptors, G-Protein-Coupled/physiology[MESH]|Receptors, Lysophospholipid[MESH]|Signal Transduction/*physiology[MESH]|Sphingosine/*analogs & derivatives/*physiology[MESH] |
