Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll Pathophysiology of the heart in Chagas disease: current status and new developments Higuchi Mde L; Benvenuti LA; Martins Reis M; Metzger MCardiovasc Res 2003[Oct]; 60 (1): 96-107In the present review we have summarized remarkable historical data on Chagas' disease studies putting special emphasis on histopathological findings and pathogenetic theories as well as recent discoveries based on the use of advanced modern technologies in pathology and immunology. A unified theory that links almost all of these findings is proposed. Chronic cardiac Chagas' disease represents the result of a close interaction between the host and the parasite, causing different clinical pictures: patients with an efficient immune response may adequately circumvent the parasitic infection and the individual will develop the indeterminate form. Deficient immune response of the host and/or a high initial parasitemia favor an immune imbalance that might lead to development of a permanent inadequate immunological response against the parasite. The inflammatory response, which is probably recurrent, undergoing periods of more accentuated exacerbation, is most likely responsible for progressive neuronal damage, microcirculatory alterations, heart matrix deformations and consequent organ failure.|*Trypanosoma cruzi/immunology[MESH]|Animals[MESH]|Antigens, CD/immunology[MESH]|Atrial Natriuretic Factor/metabolism[MESH]|Autoimmunity[MESH]|CD8-Positive T-Lymphocytes/immunology[MESH]|Cell Adhesion Molecules/immunology[MESH]|Chagas Cardiomyopathy/*etiology/immunology/parasitology[MESH]|Cytokines/immunology[MESH]|Heart/*parasitology[MESH]|Humans[MESH]|Immune Tolerance[MESH]|Natriuretic Peptide, Brain/metabolism[MESH]|Parasitemia[MESH] |