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  • Anandamide and vanilloid TRPV1 receptors
  • Ross RA
  • Br J Pharmacol 2003[Nov]; 140 (5): 790-801
  • A large body of evidence now exists to substantiate that the endocannabinoid, anandamide, activates TRPV1 receptors. It is a low intrinsic efficacy TRPV1 agonist that behaves as a partial agonist in tissues with a low receptor reserve, while in tissues with high receptor reserve and in circumstances associated with certain disease states, it behaves as a full agonist. The efficacy of anandamide as a TRPV1 agonist is influenced by a succession of factors including receptor reserve, phosphorylation, metabolism and uptake, CB1 receptor activation, voltage, temperature, pH and bovine serum albumin. There are indications that the endocannabinoid system may play a role in the modulation of TRPV1 receptor activation. The activation of TRPV1 receptors by anandamide has potential implications in the treatment of inflammatory, respiratory and cardiovascular disorders. The relative importance of anandamide as a physiological and/or pathophysiological TRPV1 receptor agonist in comparison to other potential candidates has yet to be revealed.
  • |Animals[MESH]
  • |Arachidonic Acids/*metabolism[MESH]
  • |Cannabinoid Receptor Modulators/*metabolism[MESH]
  • |Endocannabinoids[MESH]
  • |Humans[MESH]
  • |Polyunsaturated Alkamides[MESH]
  • |Receptors, Cannabinoid/metabolism[MESH]
  • |Receptors, Drug/*metabolism[MESH]





  • *{{pmid14517174}}
    *<b>[http://www.kidney.de/mlpefetch.php?search=14517174 Anandamide and vanilloid TRPV1 receptors ]</b> Br J Pharmacol 2003; 140(5) ; 790-801 Ross RA

        *14517174*

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    Br J Pharmacol

    790 5.140 2003