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The MHC class I antigen presentation pathway: strategies for viral immune evasion Hewitt EWImmunology 2003[Oct]; 110 (2): 163-9Presumably because of the selective pressure exerted by the immune system, many viruses have evolved proteins that interfere with antigen presentation by major histocompatibility complex (MHC) class I molecules. These viruses utilize a whole variety of ingenious strategies to inhibit the MHC class I pathway. Viral proteins have been characterized that exploit bottlenecks in the MHC class I pathway, such as peptide translocation by the transporter associated with antigen processing. Alternatively, viral proteins can cause the degradation or mislocalization of MHC class I molecules. This is often achieved by the subversion of the host cell's own protein degradation and trafficking pathways. As a consequence elucidation of how these viral proteins act to subvert host cell function will continue to give important insights not only into virus-host interactions but also the function and mechanism of cellular pathways.|*Immune Tolerance[MESH]|Antigen Presentation/immunology[MESH]|Down-Regulation/immunology[MESH]|Herpesviridae Infections/*immunology[MESH]|Histocompatibility Antigens Class I/*immunology[MESH]|Humans[MESH] |
