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lüll Cystatins--inhibitors of cysteine proteinases Bobek LA; Levine MJCrit Rev Oral Biol Med 1992[]; 3 (4): 307-32The cystatin superfamily of proteins, derived from a common ancestor, is comprised of a diverse group of potent cysteine proteinase inhibitors and antibacterial/viral agents grouped into several families. This review concentrates on family 2 cystatins, namely, the human salivary cystatins and cystatin C. Emphasis is given to their physicochemical and functional properties at both the protein and the molecular level. The role of cystatins in disease processes, including those in the oral cavity, is also discussed. Finally, future directions for cystatin research in oral biology are presented.|Amino Acid Sequence[MESH]|Animals[MESH]|Cystatin C[MESH]|Cystatins/chemistry/genetics/*physiology[MESH]|Cysteine Proteinase Inhibitors/chemistry/genetics/physiology[MESH]|Gene Expression Regulation[MESH]|Humans[MESH]|Molecular Sequence Data[MESH]|Salivary Proteins and Peptides/chemistry/genetics/physiology[MESH] |