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The diversity of retroviral diseases of the immune system O'Neill HCImmunol Cell Biol 1992[Jun]; 70 ( Pt 3) (ä): 193-9Retroviruses have been implicated as causative agents for a range of diseases including neoplasia, autoimmunity and immunosuppression. No two retroviruses carry the same complement of genes and for this reason it is not surprising that they induce a variety of different disease states. One common element in retroviral evolution has been the need to avoid immune recognition in order to persist within the host. A comparative approach, looking at various persistent retroviruses, has been used to pin-point the types of genetic adaptations adopted by retroviruses to remain hidden, often within the T cell compartment. Most of these retroviruses are T-cell-tropic and the diseases which they induce usually reflect the effect of the retrovirus on normal lymphocyte function.|Animals[MESH]|Antigenic Variation[MESH]|Biological Evolution[MESH]|Cats[MESH]|Defective Viruses/genetics/immunology[MESH]|Gene Expression Regulation, Viral[MESH]|Genome, Viral[MESH]|Humans[MESH]|Immunologic Deficiency Syndromes/classification/immunology/*microbiology[MESH]|Lymphoproliferative Disorders/classification/immunology/*microbiology[MESH]|Mammary Neoplasms, Experimental/microbiology[MESH]|Mice[MESH]|Retroviridae Infections/*immunology[MESH]|Retroviridae/genetics/pathogenicity/physiology[MESH]|T-Lymphocyte Subsets/immunology/microbiology[MESH]|Virus Replication[MESH] |
