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  • The main function of IL-2 is to promote the development of T regulatory cells
  • Malek TR
  • J Leukoc Biol 2003[Dec]; 74 (6): 961-5
  • Based primarily on vitro studies, interleukin (IL)-2 has been considered a key growth and death factor for antigen-activated T lymphocytes. IL-2 is also essential to maintain self-tolerance, as IL-2- and IL-2 receptor-deficient mice exhibit lethal autoimmunity. The intrinsic death-sensitizing activity of IL-2 was thought to be a key mediator for apoptosis of peripheral autoreactive T cells. However, recent in vivo studies strongly favor a model whereby IL-2 controls autoimmunity through the production of CD4+CD25+ T regulatory (Treg) cells. In this setting, IL-2 is essential for expansion of Treg cells within the thymus and in peripheral neonatal-immune tissue. Thus, from being considered the primary growth factor for antigen-activated T lymphocytes, these new findings redefine the pivotal role for IL-2 as the major inducer for the developmental production of suppressive Treg cells.
  • |Animals[MESH]
  • |Autoimmune Diseases/immunology/prevention & control[MESH]
  • |CD4-Positive T-Lymphocytes/*immunology[MESH]
  • |Interleukin-2/*physiology[MESH]
  • |Leukocyte Common Antigens/analysis[MESH]
  • |Lymphocyte Activation[MESH]
  • |Mice[MESH]
  • |Mice, Knockout[MESH]
  • |Receptors, Interleukin-2/*analysis[MESH]
  • |T-Lymphocytes, Regulatory/physiology[MESH]

  • *{{pmid12960253}}
    *<b>[ The main function of IL-2 is to promote the development of T regulatory cells ]</b> J Leukoc Biol 2003; 74(6) ; 961-5 Malek TR


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    J Leukoc Biol

    961 6.74 2003