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Molecular phylogeny within type I cytokines and their cognate receptors Boulay JL; O'Shea JJ; Paul WEImmunity 2003[Aug]; 19 (2): 159-63Type I helical cytokines are ligands for receptors structurally related by a common sequence signature. Here we analyze the 27 ligands and 34 human type I cytokine receptor encoded by the human genome. We compare these to ligands and receptors found in mouse and insects. We describe their structural relatedness to one another and discuss the evolution of these gene families.|Animals[MESH]|Anopheles/genetics/immunology[MESH]|Cytokines/classification/*genetics/metabolism[MESH]|Drosophila/genetics/immunology[MESH]|Evolution, Molecular[MESH]|Humans[MESH]|Mice[MESH]|Multigene Family[MESH]|Phylogeny[MESH]|Protein-Tyrosine Kinases/metabolism[MESH]|Receptors, Cytokine/*genetics/metabolism[MESH]|Signal Transduction[MESH]|Species Specificity[MESH]|Transcription Factors/metabolism[MESH] |
