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Advances in breast cancer treatment and prevention: preclinical studies on aromatase inhibitors and new selective estrogen receptor modulators (SERMs) Schiff R; Chamness GC; Brown PHBreast Cancer Res 2003[]; 5 (5): 228-31Intensive basic and clinical research over the past 20 years has yielded crucial molecular understanding into how estrogen and the estrogen receptor act to regulate breast cancer and has led to the development of more effective, less toxic, and safer hormonal therapy agents for breast cancer management and prevention. Selective potent aromatase inhibitors are now challenging the hitherto gold standard of hormonal therapy, the selective estrogen-receptor modulator tamoxifen. Furthermore, new selective estrogen-receptor modulators such as arzoxifene, currently under clinical development, offer the possibility of selecting one with a more ideal pharmacological profile for treatment and prevention of breast cancer. Two recent studies in preclinical model systems that evaluate mechanisms of action of these new drugs and suggestions about their optimal clinical use are discussed.|*Aromatase Inhibitors[MESH]|Animals[MESH]|Antineoplastic Combined Chemotherapy Protocols/*therapeutic use[MESH]|Breast Neoplasms/*drug therapy/enzymology/*prevention & control[MESH]|Drug Evaluation, Preclinical[MESH]|Drugs, Investigational/*therapeutic use[MESH]|Estrogen Receptor Modulators/*therapeutic use[MESH]|Humans[MESH]|Mammary Neoplasms, Experimental/*drug therapy/*enzymology/prevention & control[MESH]|Mice[MESH] |
