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lüll Gliofibroma: a case report and review of the literature Kim Y; Suh YL; Sung C; Hong SCJ Korean Med Sci 2003[Aug]; 18 (4): 625-9Gliofibroma is a rare astrocytic tumor, composed of a glial component ranging from benign to high grade of malignancy and a consistently benign mesenchymal component. Its exact biological behavior is not fully known. In addition, histogenesis and prognostic factors are also still debatable. We herein present a rare case of gliofibroma in a 25-yr-old male with seizure. A computed tomographic scan of the brain showed a 1.5 cm-sized, enhancing mass with calcification. Histologically, the tumor consisted of glial fibrillary acidic protein (GFAP)-positive glial cells admixed with a mesenchymal component and extensive collagen lay down. The glial cells displayed variable cellularity, but without mitosis or necrosis. Since the MIB-1 labeling index was up to 35.8% in the cellular areas of the glial component, it could be considered to be a predictor of worse prognosis.|Adult[MESH]|Astrocytoma/*diagnosis/pathology[MESH]|Brain Neoplasms/*diagnosis/pathology[MESH]|Glial Fibrillary Acidic Protein/biosynthesis[MESH]|Humans[MESH]|Immunohistochemistry[MESH]|Male[MESH]|Mitosis[MESH]|Necrosis[MESH]|Prognosis[MESH]|Seizures/complications[MESH]|Tomography, X-Ray Computed[MESH] |