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lüll Role of Na-K-ATPase in the assembly of tight junctions Rajasekaran AK; Rajasekaran SAAm J Physiol Renal Physiol 2003[Sep]; 285 (3): F388-96Na-K-ATPase, also known as the sodium pump, is a crucial enzyme that regulates intracellular sodium homeostasis in mammalian cells. In epithelial cells Na-K-ATPase function is also involved in the formation of tight junctions through RhoA GTPase and stress fibers. In this review, a new two-step model for the assembly of tight junctions is proposed: step 1, an E-cadherin-dependent formation of partial tight junction strands and of the circumferential actin ring; and step 2, active actin polymerization-dependent tethering of tight junction strands to form functional tight junctions, an event requiring normal function of Na-K-ATPase in epithelial cells. A new role for stress fibers in the assembly of tight junctions is proposed. Also, implications of Na-K-ATPase function on tight junction assembly in diseases such as cancer, ischemia, hypomagnesemia, and polycystic kidney disease are discussed.|Animals[MESH]|Cadherins/metabolism[MESH]|Disease[MESH]|Humans[MESH]|Mitogen-Activated Protein Kinases/metabolism[MESH]|Sodium-Potassium-Exchanging ATPase/*metabolism[MESH]|Stress Fibers/metabolism[MESH]|Tight Junctions/chemistry/*enzymology/*metabolism[MESH] |