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Recombinant human PTH 1-34 (Forteo): an anabolic drug for osteoporosis Deal C; Gideon JCleve Clin J Med 2003[Jul]; 70 (7): 585-6, 589-90, 592-4 passimForteo (teriparatide of rDNA origin), a genetically engineered fragment of parathyroid hormone, is the first of a new class of drugs to treat osteoporosis. The drug's anabolic action increases bone turnover, stimulating osteoblasts to a greater extent than osteoclasts, and reducing both vertebral and nonvertebral fractures. However, a number of issues about its use remain unanswered.|Amino Acid Sequence[MESH]|Animals[MESH]|Bone Density/drug effects[MESH]|Bone and Bones/drug effects/pathology[MESH]|Clinical Trials as Topic[MESH]|Contraindications[MESH]|Fractures, Bone/prevention & control[MESH]|Humans[MESH]|Molecular Sequence Data[MESH]|Osteoporosis/*drug therapy/pathology[MESH]|Practice Guidelines as Topic[MESH]|Recombinant Proteins/economics/*therapeutic use[MESH]|Teriparatide/economics/*therapeutic use[MESH] |
