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Signaling transduction by IgG receptors Pan L; Pei PChin Med J (Engl) 2003[Apr]; 116 (4): 487-94OBJECTIVE: To review and summarize literature regarding stimulatory and inhibitory signaling pathways from different types of Fc gamma receptors (FcgammaRs). DATA SOURCE: Articles were obtained from Medline from January 1991 to April 2002. STUDY SELECTION: Over 100 English language papers and reviews published over the last 11 years were selected. RESULTS AND CONCLUSIONS: Stimulatory Fcgamma receptors include FcgammaRI, FcgammaRIIA, FcgammaRIIC, and FcgammaRIII A. They transduce signals through the immunoreceptor tyrosine-based activation motif (ITAM) in subunits or in the cytoplasmic domain. Inhibitory Fcgamma receptors, such as FcgammaRIIB, are single chain receptors, transducing signals through an immunoreceptor tyrosine-based inhibitory motif (ITIM) in cytoplasmic domains. Stimulatory signals include protein phosphorylation, increase in intracellular free calcium, the production of 1,4,5-triphosphate inositol (IP(3)) and diacylglycerol (DAG) mainly through the Src-family kinases, phosphoinositide 3-kinase (PI3-K) and phospholipase C (PLC). Inhibitory signaling has been implicated in the repression of the above activities as well as inhibition of B cell responses through Src homology 2-containing inositol phosphatase (SHIP).|Amino Acid Motifs[MESH]|Animals[MESH]|Blood Platelets/physiology[MESH]|Humans[MESH]|Phagocytes/physiology[MESH]|Receptors, IgG/chemistry/*physiology[MESH]|Signal Transduction/*physiology[MESH] |
