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lüll New molecular pathways in angiogenesis Sullivan DC; Bicknell RBr J Cancer 2003[Jul]; 89 (2): 228-31Angiogenesis has developed into a major area of cancer research. Recently, several newly identified signalling pathways have been shown to play a role in both normal and pathological (including tumour) angiogenesis. Several of the molecules involved in these pathways have potential as novel anti-cancer therapeutic targets including members of the ephrin/Eph receptor, Notch/delta, sprouty, hedgehog and roundabout/slit families. These developments are reviewed.|Ephrins/*pharmacology[MESH]|Hedgehog Proteins[MESH]|Humans[MESH]|Ligands[MESH]|Membrane Proteins/pharmacology[MESH]|Neoplasms/*genetics/*physiopathology[MESH]|Neovascularization, Pathologic/*genetics[MESH]|Receptors, Eph Family/*physiology[MESH]|Receptors, Notch[MESH]|Signal Transduction[MESH]|Trans-Activators/pharmacology[MESH] |