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lüll Targeting Aurora-2 kinase in cancer Warner SL; Bearss DJ; Han H; Von Hoff DDMol Cancer Ther 2003[Jun]; 2 (6): 589-95Aurora-2 kinase has been shown to contribute to oncogenic transformation and is frequently overexpressed and amplified in many human tumor types. Aurora-2 belongs to a small family of mitotic serine/threonine kinases that regulate centrosome maturation, chromosome segregation, and cytokinesis. The mechanism behind the transforming activity of aurora-2 is not fully understood; however, the role of aurora-2 in regulating the centrosome cycle is likely responsible for its ability to transform cells. Aurora-2 overexpression has been correlated with centrosome amplification, which can be a driving cause of genomic instability in tumor cells. In addition, recent work has demonstrated that aurora-2 plays an active function in promoting entry into mitosis by regulating local translation of centrosomal stored mRNA, such as cyclin B1. These recent findings implicate aurora-2 as an important regulator of both genomic integrity and cell cycle progression in cancer cells and suggest that aurora-2 is an attractive target for anticancer drug development.|Antineoplastic Agents/pharmacology[MESH]|Aurora Kinases[MESH]|Centrosome/ultrastructure[MESH]|Cyclin B/metabolism[MESH]|Cyclin B1[MESH]|Gene Expression Regulation, Neoplastic[MESH]|Mitosis[MESH]|Models, Biological[MESH]|Neoplasms/*enzymology[MESH]|Protein Biosynthesis[MESH]|Protein Serine-Threonine Kinases/antagonists & inhibitors/genetics/*physiology[MESH]|RNA, Messenger/metabolism[MESH] |