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AIP1: a new player in TNF signaling Guicciardi ME; Gores GJJ Clin Invest 2003[Jun]; 111 (12): 1813-5Apoptosis signal-regulating kinase 1 (ASK1) is an upstream activator of JNK and p38 MAPK signaling cascades. Evidence now shows that the ASK1-interacting protein, AIP1, plays an important role in TNF-alpha-induced ASK1 activation by facilitating dissociation from its inhibitor.|Antigens, CD/physiology[MESH]|Apoptosis/physiology[MESH]|Enzyme Activation[MESH]|Enzyme Inhibitors/metabolism[MESH]|Humans[MESH]|MAP Kinase Kinase Kinase 5[MESH]|MAP Kinase Kinase Kinases/antagonists & inhibitors/*physiology[MESH]|MAP Kinase Signaling System[MESH]|Receptors, Tumor Necrosis Factor, Type I[MESH]|Receptors, Tumor Necrosis Factor, Type II[MESH]|Receptors, Tumor Necrosis Factor/physiology[MESH]|Tumor Necrosis Factor-alpha/*physiology[MESH]|ras GTPase-Activating Proteins/*physiology[MESH] |
