Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve Pubget Overpricing |
lüll T-tubule function in mammalian cardiac myocytes Brette F; Orchard CCirc Res 2003[Jun]; 92 (11): 1182-92The transverse tubules (t-tubules) of mammalian cardiac ventricular myocytes are invaginations of the surface membrane. Recent studies have suggested that the structure and function of the t-tubules are more complex than previously believed; in particular, many of the proteins involved in cellular Ca2+ cycling appear to be concentrated at the t-tubule. Thus, the t-tubules are an important determinant of cardiac cell function, especially as the main site of excitation-contraction coupling, ensuring spatially and temporally synchronous Ca2+ release throughout the cell. Changes in t-tubule structure and protein expression occur during development and in heart failure, so that changes in the t-tubules may contribute to the functional changes observed in these conditions. The purpose of this review is to provide an overview of recent studies of t-tubule structure and function in cardiac myocytes.|Animals[MESH]|Calcium/metabolism[MESH]|Cardiomegaly/metabolism/pathology[MESH]|Guinea Pigs[MESH]|Heart Failure/metabolism/pathology[MESH]|Heart/embryology/growth & development[MESH]|Humans[MESH]|Ion Transport[MESH]|Mammals/*physiology[MESH]|Membrane Proteins/analysis[MESH]|Mice[MESH]|Myocytes, Cardiac/chemistry/*physiology/ultrastructure[MESH]|Rabbits[MESH]|Rats[MESH]|Sarcolemma/chemistry/*physiology/ultrastructure[MESH]|Signal Transduction[MESH]|Swine[MESH] |