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Bench-to-bedside review: severe lactic acidosis in HIV patients treated with nucleoside analogue reverse transcriptase inhibitors Claessens YE; Chiche JD; Mira JP; Cariou ACrit Care 2003[Jun]; 7 (3): 226-32Nucleoside reverse transcriptase inhibitors (NRTIs) are effective antiretroviral therapy for the treatment of HIV-infected patients. NRTIs can induce mitochondrial impairment that leads to a number of adverse events, including symptomatic lactic acidosis. In the present review, we describe the underlying mechanism of NRTI-induced toxicity and the main clinical features of this infrequent, but severe, emerging complication. We also summarise experimental data and clinical observations that support the use of L-carnitine supplementation to reverse NRTI-induced mitochondrial impairment.|Acidosis, Lactic/*chemically induced/diagnosis/drug therapy/metabolism[MESH]|Adult[MESH]|Anti-HIV Agents/*adverse effects[MESH]|Carnitine/therapeutic use[MESH]|HIV Infections/*drug therapy[MESH]|Humans[MESH]|Lactic Acid/metabolism[MESH]|Mitochondria/drug effects[MESH]|Nucleosides/*adverse effects[MESH]|Reverse Transcriptase Inhibitors/*adverse effects[MESH] |
