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lüll Mechanisms of ventilator-induced lung injury: the clinician s perspective Michaud G; Cardinal PCrit Care 2003[Jun]; 7 (3): 209-10In the present issue of Critical Care, Frank and Matthay review the physiologic mechanisms that lead to ventilator-induced lung injury. Our greater understanding of basic physiologic principles has already had a major impact on the treatment of critically ill patients. Novel strategies to limit ventilator-induced lung injury have now been shown to improve survival. However, there has been debate in the literature regarding the safety and efficacy of the Acute Respiratory Distress Syndrome (ARDS) Network study protocol in reducing ventilator-induced lung injury. The issues surrounding the ARDS Network protocol and a recent meta-analysis criticizing its use are presented. As clinicians, we now have the responsibility to ensure that our patients benefit from these recent developments.|Clinical Protocols[MESH]|Humans[MESH]|Meta-Analysis as Topic[MESH]|National Institutes of Health (U.S.)[MESH]|Pulmonary Alveoli/injuries[MESH]|Respiration, Artificial/*adverse effects/methods[MESH]|Respiratory Distress Syndrome/*etiology/physiopathology/prevention & control[MESH]|Survival Analysis[MESH]|United States[MESH]|Ventilators, Mechanical/*adverse effects[MESH] |