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lüll IQGAP proteins are integral components of cytoskeletal regulation Briggs MW; Sacks DBEMBO Rep 2003[Jun]; 4 (6): 571-4IQGAP1 is a scaffolding protein that binds to a diverse array of signalling and structural molecules. By interacting with its target proteins, human IQGAP1 participates in multiple cellular functions, including Ca(2+)/calmodulin signalling, cytoskeletal architecture, CDC42 and Rac signalling, E-cadherin-mediated cell-cell adhesion and beta-catenin-mediated transcription. Yeast IQGAP homologues are important regulators of cellular morphogenesis because they are required for budding and cytokinesis. Here we discuss the structure and function of IQGAP1 as a member of the family of IQGAP proteins and summarize the current knowledge about IQGAP1 and IQGAP2. Collectively, these data reveal that IQGAP1 is a fundamental regulator of cytoskeletal function.|*ras GTPase-Activating Proteins[MESH]|Animals[MESH]|Cell Division[MESH]|Cytoskeletal Proteins/metabolism[MESH]|Cytoskeleton/*metabolism[MESH]|Humans[MESH]|Microfilament Proteins/*chemistry/*physiology[MESH]|Models, Biological[MESH]|Neoplasms/metabolism[MESH]|Protein Binding[MESH]|Protein Structure, Tertiary[MESH]|Signal Transduction[MESH]|Trans-Activators/metabolism[MESH]|Transcription, Genetic[MESH]|beta Catenin[MESH] |