Warning: Undefined variable $zfal in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Deprecated: str_replace(): Passing null to parameter #3 ($subject) of type array|string is deprecated in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 525
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 530
Warning: Undefined variable $sterm in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 531
Warning: file_get_contents(http://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=12764038&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\mlpefetch.php on line 445
 
English Wikipedia
Nephropedia Template TP (
Twit Text
DeepDyve
Pubget Overpricing |  
lüll
The reelin signaling pathway: some recent developments Jossin Y; Bar I; Ignatova N; Tissir F; De Rouvroit CL; Goffinet AMCereb Cortex 2003[Jun]; 13 (6): 627-33The Reelin signaling pathway plays a key role in the architectonic development of the central nervous system. Extracellular Reelin binds to receptors of the lipoprotein receptor family and induces tyrosine phosphorylation of the adaptor Dab1. In this paper, we discuss three recent developments. First, we show that the central part of Reelin is involved in receptor binding and signal activation as reflected in Dab1 phosphorylation. Second, we examine the genomic organization, alternative splicing and promoter use of the Dab1 gene, which hint at a particularly complex regulation. Third, we present preliminary studies by in situ hybridization that demonstrate regulated expression of Reelin receptors and Dab1 by radial precursors in the ventricular zone.|Cell Adhesion Molecules, Neuronal/chemistry/*genetics/*metabolism[MESH]|Cerebral Cortex/embryology/metabolism[MESH]|Extracellular Matrix Proteins/chemistry/*genetics/*metabolism[MESH]|Fungal Proteins/genetics/*metabolism[MESH]|Gene Expression Regulation, Developmental[MESH]|LDL-Receptor Related Proteins[MESH]|Macromolecular Substances[MESH]|Nerve Tissue Proteins[MESH]|Neurons/*metabolism[MESH]|Receptors, LDL/metabolism[MESH]|Receptors, Lipoprotein/metabolism[MESH]|Reelin Protein[MESH]|Serine Endopeptidases[MESH]|Signal Transduction/*physiology[MESH] |
