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lüll Innate self recognition by an invariant, rearranged T-cell receptor and its immune consequences Stanic AK; Park JJ; Joyce SImmunology 2003[Jun]; 109 (2): 171-84This review attempts to illuminate the glycolipid antigen presentation properties of CD1d, how CD1d controls the function of natural T (iNKT) cells and how CD1d and iNKT cells interact to jump-start the immune system. It is postulated that the CD1d-iNKT cell system functions as a sensor, sensing alterations in cellular lipid content by virtue of its affinity for such ligands. The presentation of a neo-self glycolipid, presumably by infectious assault of antigen-presenting cells, activates iNKT cells, which promptly release pro-inflammatory and anti-inflammatory cytokines and jump-start the immune system.|Antigen Presentation/immunology[MESH]|Antigens, CD1/*immunology[MESH]|Antigens, CD1d[MESH]|Cell Differentiation/immunology[MESH]|Cytokines/immunology[MESH]|Humans[MESH]|Immunity, Cellular[MESH]|Killer Cells, Natural/*immunology[MESH]|Models, Immunological[MESH]|T-Lymphocyte Subsets/*immunology[MESH] |