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Long-term potentiation and the ageing brain Barnes CAPhilos Trans R Soc Lond B Biol Sci 2003[Apr]; 358 (1432): 765-72Ageing is associated with learning and memory impairments. Data are reviewed that suggest that age-related impairments of hippocampal-dependent forms of memory, may be caused, in part, by altered synaptic plasticity mechanisms in the hippocampus, including long-term potentiation (LTP). To the extent that the mechanisms responsible for LTP can be understood, it may be possible to develop therapeutic approaches to alleviate memory decline in normal ageing.|Aging/*physiology[MESH]|Animals[MESH]|Behavior, Animal/physiology[MESH]|Brain Mapping[MESH]|Brain/*physiology[MESH]|Electrophysiology[MESH]|Hippocampus/physiology[MESH]|Long-Term Potentiation/*physiology[MESH]|Memory/physiology[MESH]|Neuronal Plasticity/physiology[MESH]|Synapses/physiology[MESH] |
