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lüll IQGAP1 as signal integrator: Ca2+, calmodulin, Cdc42 and the cytoskeleton Briggs MW; Sacks DBFEBS Lett 2003[May]; 542 (1-3): 7-11A family of proteins known as IQGAPs have been identified in yeast, amebas and mammals. IQGAPs are multidomain molecules that contain several protein-interacting motifs which mediate binding to target proteins. Mammalian IQGAP1 is a component of signaling networks that are integral to maintaining cytoskeletal architecture and cell-cell adhesion. Published data suggest that IQGAP1 is a scaffolding protein that modulates cross-talk among diverse pathways in complex regulatory circuits. These pathways include modulating the actin cytoskeleton, mediating signaling by Rho family GTPases and calmodulin, regulating E-cadherin and beta-catenin function and organizing microtubules.|*Calcium Signaling[MESH]|*ras GTPase-Activating Proteins[MESH]|Animals[MESH]|Calmodulin/physiology[MESH]|Carrier Proteins/chemistry/*physiology[MESH]|Cytoskeleton/metabolism[MESH]|Models, Biological[MESH]|Protein Structure, Tertiary[MESH]|cdc42 GTP-Binding Protein/physiology[MESH] |